(論文,解説)
Sekiyama, Y and Kikuchi, J. "Toward dynamic metabolic network measurement
by multi-dimensional NMR-based fluxomics" Phytochemistry 68(16-18):2320-9
(2007).
Tian C.J. Chikayama, E., Tsuboi, Y., Kuromori, T., Shinozaki, K., Kikuchi,
J. and Hirayama, T. "Top-down phenomics of Arabidopsis thaliana -One
and two-dimensional NMR metabolic profiling and transcriptome analysis of
albino mutants". J. Biol. Chem. 282(25):18532-41(2007).
Kikuchi, J. & Hirayama, T. "Practical aspects of stable isotope
labeling of higher plants for a hetero-nuclear multi-dimensional NMR-based
metabolomics". Method Mol. Biol. 358, 273-286 (2006).
Sasaki, R., Sasaki, H., Fukuzawa, S., Kikuchi, J., Hirota, H. & Tachibana,
K. "Thermal analyses of phospholipid mixtures by differential scanning
calorimetry and effect of doping with a bolaform amphiphile" Bull.
Chem. Soc. Jpn. in press (2006).
Kikuchi, J、Akamine, K. "in vivo NMR" J.Spect.Soc., 55, 320-330 (2006).
Kikuchi, J. & Hirayama, T. "Hetero-nuclear NMR-based metabolomics"
Biotech. Agri. Forest. 57, 93-101 (2006).
Elmi, M. M., Aminiasaab, M., Hondo, T., Kikuchi, J., Kuroda, Y., Naderi-Manesh,
H. & Sarbolouki, M. M. "Structural and functional characterization
of a mutant of Pseudocerastes persicus natriutic peptide" Prot. Pept.
Lett. 13, 295-300 (2006).
Fukuda, S., Suzuki, Y., Murai, M., Asanuma, N., and Hino, T.: "A novel
strain of Butyrivibrio fibrisolvens that isomerizes linoleic acid to conjugated
linoleic acid without hydrogenating to trans-vaccenic acid, and its utilization
as a probiotic for animals." J. Appl. Microbiol. 100, 787-794 (2006).
Fukuda, S., Suzuki, Y., Murai, M., Asanuma, N., and Hino, T.: "Augmentation
of vaccenate production and suppression of vaccenate biohydrogenation in
cultures of mixed ruminal microbes." J. Dairy Sci. 89, 1043-1051 (2006).
Izumikawa, M., Cheng, Q. and Moore, B.S. "Priming type II polyketide
synthases via a type II nonribosomal peptide synthetase mechanism."
J. Am. Chem. Soc. 128, 1428-1429 (2006).
Sato, S., Nakano, Y., Nishikubo, N., Tsuboi, Y., Kajita, S., Zhou, J., Kitano,
H. and Katayama, Y. "The specific expression of transcripts encoding
enzymes of the shikimate pathway for the ectopic accumulation of polysaccharide-linked
hydroxycinnamoyl esters in internode parenchyma cell walls of rice mutant
Fukei 71" Plant Cell Reports, in press
Zhao, B., Guengerich, F. P., Bellamine, A., Lamb, D. C., Izumikawa, M.,
Lei, L., Podust, L. M., Sundaramoorthy, M., Kalaitzis, J. A., Reddy, L.
M., Kelly, S. L., Moore, B. S., Stec, D., Voehler, M., Falck, J. R., Shimada,
T. & Waterman, M. R. "Binding of two flaviolin substrate molecules,
oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2)
cytochrome P450 158A2" J. Biol. Chem. 280, 11599-11607 (2005).
Fukuda, S., Furuya, H., Suzuki, Y., Asanuma, N., and Hino, T.: "A new
strain of Butyrivibrio fibrisolvens that has high ability to isomerize linoleic
acid to conjugated linoleic acid." J. Gen. Appl. Microbiol. 51 105-113
(2005).
Horiuchi, T., Takahashi, M., Kikuchi, J., Yokoyama, S. & Maeda, H. (2005)
"Effect of dielectric properties of solvents on the quality factor
for a beyond 900 MHz cryogenic probe model" J. Magn. Reson. 174, 33-41.
Mase, K., Sato, K., Nakano, Y., Nishikubo, N., Tsuboi, Y., Zhou, H., Kitano,
H. and Katayama, Y. "The ctopic expression of phenylalanine ammonia
lyase with ectopic accumulation of polysaccharide-linked hydroxycinnamoyl
esters in internode parenchyma of rice mutant Fkei 71" Plant Cell Reports
24, 487-493 (2005)
(国際会議)
E. Chikayama, M. Okamoto, Y. Nakanishi, T. Hirayama, K. Saito, and J.
Kikuchi, "Multidimensional NMR-based Metabolomics with SpinAssign:
Metabolite Identification in NMR Spectra of Crude Extracts using a Robust
Metabolite Chemical Shift Database", Metabolomics Society 3rd Annual
Conference(Metabolomics 2007), Manchester, UK, (2007)
Kikuchi, J., Chikayama, E., Tsuboi, Y., Nakanishi, Y., Okamoto, M. Shinozaki,
K. & Hirayama, T. "Metabolic profiling and molecular identifications
of stable isotope labeled plant, animal and bacterial systems" 22th
International Conference on Magnetic Resonance in Biological Systems,
Gottingen (2006).
Nakanishi, Y., Fukuda, S., Ohno, H. & Kikuchi, J. "Metabolic
dynamics analysis of the symbiosys microorganisms by in vivo and in vitro
NMR" 22th International Conference on Magnetic Resonance in Biological
Systems, Gottingen (2006).
Okamoto, M., Hirayama, T. & Kikuchi, J. "Methodological advances
for NMR monitoring of metabolic changes of uniformly stable isotope labeled
plant cells" 22th International Conference on Magnetic Resonance
in Biological Systems, Gottingen (2006).
Blazina, D., Kikuchi, J. & Raynolds, S. "Application of DNP NMR
to plant science" 22th International Conference on Magnetic Resonance
in Biological Systems, Gottingen (2006).
Maeno, A., Nakano, M., Yamaguchi, Y., Sasakawa, H., Kurimoto, E., Asami,
O., Kajino, T., Oka, T., Nakasako, M., Kikuchi, J. & Kato, K. "Structural
basis of enzymatic mechanisms of protein disulfide isomerase" 22th
International Conference on Magnetic Resonance in Biological Systems,
Gottingen (2006).
Kikuchi, J. & Izumikawa, M. "Stable isotope labeling of photosynthetic
bacteria for a hetero-nuclear NMR-based metabolomics" 12th International
Symposium on Phototrophic Prokaryotes, Pau (2006).
Kikuchi, J., Chikayama, E., Izumikawa, M., Tian, C., Tsuboi, Y., Saito,
K. Shinozaki, K. & Hirayama, T. "From 1D to nD-NMR : Technical
advantage for novel metabolic profiling, efficient molecular identification
and application to chemical biology research" 2nd International Metabolomics
Conference, Boston (2006).
Izumikawa, M., Saito, K., Shinozaki, K., Hirayama, T. & Kikuchi, J.
"Development of analytical systems for chemical responses on plant
metabolism" 2nd International Metabolomics Conference, Boston (2006).
Tian, C., Tsuboi, Y., Chikayama, E., Sekiyama, Y., Kuromori, T., Shinozaki,
K., Hirayama, T. and Kikuchi, J. "An efficient strategy for the metabolic
characterization of Arabidopsis mutants with visible and silent phenotypes
by fast 1D-NMR followed by multi-dimensional NMR analysis" 2nd International
Metabolomics Conference, Boston (2006).
Hirayama, T., Tsuboi, T., Shinozaki, K. and Kikuchi, J. "Toward an
NMR-based nutrigenomics assisted by stable isotope labeling of plants
through animals" 2nd International Metabolomics Conference, Boston
(2006).
Kikuchi, J., Sekiyama, Y., Chikayama, E., Izumikawa, M., Tsuboi, Y., Saito,
K., Shinozaki, K. and Hirayama T. "Methodological advancements for
efficient molecular identification and reaction analysis for a hetero-nuclear
NMR-based metabomics" 20th IUBMB International Congress of Biochemistry
and Molecular Biology and 11th FAOBMB Congress, Kyoto (2006).
Tsuboi, Y., Hirayama, T., Shinozaki, K. and Kikuchi, J. "Toward an
NMR-based nutrigenomics assisted by stable isotope labeling of plants
through animals" 20th IUBMB International Congress of Biochemistry
and Molecular Biology and 11th FAOBMB Congress, Kyoto (2006).
Fukuda, S. and Kikuchi, J. Novel approach for metabolic analysis of gut
microfloral intermediated reactions by multi-dimensional NMR" 20th
IUBMB International Congress of Biochemistry and Molecular Biology and
11th FAOBMB Congress, Kyoto (2006).
Hirayama, T., Tian, C., Tsuboi, Y., Chikayama E., Sekiyama, Y., Kuromori,
T., Shinozaki, K. and Kikuchi, J. "Advances in hetero-nuclear NMR
based metabolomics approach in plant systems" 20th IUBMB International
Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress,
Kyoto (2006).
Kikuchi, J., Tsuboi, Y., Shinozaki, K. and Hirayama, T. "Stable isotope
labeling of plants through animals for a hetero-nuclear NMR-based nutrition
profiling. 1st International Conference on Nutrigenomics and Gut Health,
Auckland (2006).
Chikayama, E., Sekiyama, Y., Hirayama, T., Saito, K., Shinozaki, K. and
Kikuchi, J. "SpinAssign, an integrated spectrum analysis system for
a hetero-nuclear NMR-based metabomics" 47th Experimental Nuclear
Magnetic Resonance Conference, Asilomer (2006).
Kikuchi, J., Sekiyama, Y., Chikayama, E., Tsuboi, Y., Saito, K., Shinozaki,
K. and Hirayama, T. "Molecular structure analysis and its metabolic
flow measurements at atomic level by a hetero-nuclear NMR" 4th International
Plant Metabolomics Conference, Reading, (2006).
Sekiyama, Y., Chikayama, E., Hirayama, T., Saito, K., Shinozaki, K. and
Kikuchi, J. "Methodological advances in hetero-nuclear NMR-based
metabolomics - Stable isotope labeling of Arabidopsis thaliana towards
metabolic flux analysis" 4th International Plant Metabolomics Conference,
Reading, (2006).
Yamaguchi, Y., Maeno, A., Nakano, M., Murakami, C., Sasakawa, H., Harada,
T., Kurimoto, E., Iguchi, T., Inaba, K., Asami, O., Kajino, T., Kikuchi,
J. & Kato, K. "Redox-dependent conformational rearrangement of
protein disulfide isomerase" 1st Asia-pacific NMR International Conference,
Yokohama (2005).
Kikuchi, J. "Development of uniformly stable isotope labeling system
in higher plants for hetero-nuclear NMR experiments in vitro and in vivo"
17th International Conference on Botanical Congress, Vienna (2005).
Kikuchi, J. & Hirayama, T. "Novel methods for uniform stable
isotope labeling of plant and animal systems followed with a hetero-nuclear
NMR-based metabomics" 1st International Metabolomics Conference,
Tsuruoka (2005).
Sekiyama, Y., Chikayama, E., Hirayama, T., Sinozaki, K., Saito, K. &
Kikuchi, J. "An efficient sampling method for a hetero-nuclear NMR-based
metabolomics" 1st International Metabolomics Conference, Tsuruoka
(2005).
Chikayama, E., Sekiyama, Y., Sinozaki, K., Saito, K. & Kikuchi, J.
"A novel method for metabolic profiling of hetero-nuclear NMR spectra
based on pattern recognition algorithm" 1st International Metabolomics
Conference, Tsuruoka (2005).
Kikuchi, J., Nishihara, T., Shinozaki, K. & Hirayama, T. "The
hetero-nuclear NMR-based metabol(n)omics in plant and animal systems"
21th International Conference on Magnetic Resonance in Biological Systems,
Hyderabad (2005).
Akamine, K. Hirayama, T., & Kikuchi, J. "The hetero-nuclear NMR-based
metabolomics reveals incorporation of 13C, 15N-compounds into higher plants"
21th International Conference on Magnetic Resonance in Biological Systems,
Hyderabad (2005).
26) Suto, M. Nishihara, T. & Kikuchi, J. "Development of uniformly
13C, 15N labeling methods in animal system for a hetero-nuclear NMR-based
metabolomics" 21th International Conference on Magnetic Resonance
in Biological Systems, Hyderabad (2005).
(国内会議)
菊地淳, 森哲哉, 雪真弘, 守屋繁春, 平山隆志, "植物バイオマスへの13C代謝動態・分解過程追跡の試み, 第46回NMR討論会、札幌、(2007)
近山英輔, 菊地淳, "新しいNMR分光法:時間周波数NMR分光法の試み", 第46回NMR討論会、札幌、(2007)
中西裕美子, 福田真嗣, 近山英輔, 木村悠一, 大野博司, 菊地淳, "NMR計測を用いた栄養源変化に対する腸内細菌の代謝動態解析",
第46回NMR討論会、札幌、(2007)
Steven Reynolds, Takamasa Abe, and Jun Kikuchi, "Analysis of Plant
Metabolites by DNP-NMR", 第46回NMR討論会、札幌、(2007)
菊地淳、古田拓、持田恵一、篠崎一雄、荻原保成 "NMR代謝プロファイリングに基づく穀物種子の簡易的有用形質評価法の開発" 日本分子生物学会2006フォーラム、 名古屋 (2006)
秋山顕治,近山英輔、菊地淳,嶋田幸久,湯浅裕亮,大林武,真保陽子,峠隆之,平井優美,金谷重彦,篠崎一雄,斉藤和季,櫻井哲也 "PRIMe;
トランスクリプトーム/メタボロームゲートウェイの開発とその進捗" 日本分子生物学会2006フォーラム、 名古屋 (2006)
雪真弘、守屋繁春、戸高眠、井上徹志、菊地淳、工藤俊章 "生物間共生の包括的理解に向けて-シロアリ複合生物系をモデルとした統合的解析の試み"
日本分子生物学会2006フォーラム、 名古屋 (2006)
茂木浩美、坪井裕理、菊地淳、平山隆志、権藤洋一、野田哲生 "マウス変異体リソースの生活習慣病様代謝疾患解析を目指したNMRメタボロームの試み" 日本分子生物学会2006フォーラム、 名古屋 (2006)
雪真弘、守屋繁春、戸高眠、井上徹志、菊地淳、工藤俊章 "複合生物間相互作用解析の試み-メタボローム・インタラクトームの確立に向けて"
第7回極限微生物学会年会、 東京 (2006)
Kikuchi, J. "Metabolite mixture analysis attracts NMR researcher's
attention" 第45回NMR討論会、京都 (2006)
Reynolds, S., Kikuchi, J. and Blazina, D. "DNP NMR in multi-component
systems" 第45回NMR討論会、京都 (2006)
Izumikawa, M., Hirayama, T., Saito, K., Shinozaki, K. and Kikuchi, J.
"Metabolomics approach of plant cellular chemical biology by flow
probe system" 第45回NMR討論会、京都 (2006)
Sekiyama, Y., Hirayama, T., Shinozaki, K. and Kikuchi, J. "Signal
enhancement by improved extraction procedures and its application to metabolic
flux analysis" 第45回NMR討論会、京都 (2006)
Mori, T., Hirayama, T. and Kikuchi, J. "Comparison of solution-state
and MAS-NMR spectra of stable isotope labeled Populus" 第45回NMR討論会、京都
(2006)
Okamoto, M., Hirayama, T. and Kikuchi, J. "Atomic redistribution
of metabolism in a plant cell system" 第45回NMR討論会、京都 (2006)
Nakanishi, Y., Fukuda, S., Ohno, H. and Kikuchi, J. "Strategies of
metabolic profiling of bacterial and animal systems" 第45回NMR討論会、京都
(2006)
菊地淳 "NMR法の特性を活かした代謝産物群解析" 第1回メタボロームシンポジウム、鶴岡 (2006)
雪真弘、守屋繁春、菊地淳、工藤俊章 "複合生物間相互作用解析系の構築 -安定同位体標識・NMR計測・RNAi"第1回メタボロームシンポジウム、 鶴岡 (2006)
菊地淳、持田恵一、篠崎一雄、荻原保成 "イネ科穀物のNMRスペクトラルフェノタイピングの試み"第70回日本植物学会年会、熊本 (2006)
大山清、鈴木雅志、関光、菊地淳、Xiang Ting、久代哲夫、渋谷雅明、海老塚豊、斉藤和季、村中俊哉 "植物ラノステロール合成酵素の同定" 第24回植物分子生物学会大会 つくば (2006)
雪真弘、守屋繁春、菊地淳、工藤俊章 "シロアリ・微生物共生系における遺伝子発現・共生代謝解析システムの構築"第14回分子寄生虫学ワークショップ、 草津 (2006)
前野亜弥、中野路子、岡俊彦、山口芳樹、笹川拡明、栗本英治、浅野修、梶野勉、菊地淳、中迫雅由、加藤晃一 "プロテインジスルフィドイソメラーゼの活性部位の酸化・還元状態の変化に伴う立体構造変化" 第33回生体分子科学討論会、名古屋(2006)
菊地淳、関山恭代、近山英輔、福田真嗣、中西裕美子、坪井裕理、斉藤和季、篠崎一雄、平山隆志 "NMR法の特性を活かしたメタボローム基盤技術開発 日本農芸化学会大会2006、京都 (2006)
関山恭代、近山英輔、平山隆志、篠崎一雄、斉藤和季、菊地淳 "安定同位体標識化による多次元NMRメタボローム解析法の開発と代謝動態析の検討" 日本農芸化学会大会2006、京都 (2006)
福田真嗣、福田常男、菊地淳 "共役リノール酸生成菌、Butyrivibrio fibrisolvensによるリノレン酸水素添加反応経路のin
vivo NMR動態解析" 日本農芸化学会大会2006、京都 (2006)
中西裕美子、福田真嗣、大野博司、菊地淳 "多次元NMRメタボローム基盤技術開発に基づく病原性大腸菌O157・ビフィズス菌共生時の代謝動態解析" 日本農芸化学会大会2006、京都 (2006)
田春杰、坪井裕理、近山英輔、関山恭代、黒森崇、篠崎一雄、平山隆志、菊地淳 "多次元NMRメタボロミクスの基盤整備と植物代謝物解析への応用" 第47回日本植物生理学会年会、つくば (2006)
森哲哉、西窪伸之、出村拓、平山隆志、菊地淳 "非侵襲NMR計測によるメタボローム解析の試み" 第47回日本植物生理学会年会、つくば (2006)
岡本真美、平山隆志、菊地淳 "均一安定同位体標識化植物細胞を用いた2次元NMR法代謝動態解析技術開発の試み" 第47回日本植物生理学会年会、つくば (2006)
菊地淳、須藤倫崇、坪井裕理、村田卓也、唐牛久美子、斉藤和季、野田哲生、権藤洋一、篠崎一雄、平山隆志 "多次元NMRメタボローム解析のための動植物代謝動態差を考慮した均一安定同位体標識技術高度化" 第28回日本分子生物学会年会、福岡(2005)
平山隆志、坪井裕理、篠崎一雄、菊地淳 "植物ホルモン応答時における均一安定同位体標識化培養細胞・個体のin vitro, in vivo多次元NMRメタボローム解析" 第28回日本分子生物学会年会、福岡(2005)
前野亜弥、山口芳樹、笹川拡明、中野路子、浅野修、梶野勉、菊地淳、加藤晃一 "プロテインジスルフィドイソメラーゼの活性部位の酸化・還元状態の変化に伴う基質結合ドメインの立体構造変化" 第28回日本分子生物学会年会、福岡(2005)
Kikuchi, J (2005) "The hetero-nuclear NMR-based metabomics by uniform
stable isotope labeling in plant and animal systems" 第44回NMR討論会,
横浜 (2005).
Sekiyama, Y., Chikayama, E., Hirayama, T., Saito, K., Sinozaki, K. &
Kikuchi, J. "Methodological advances of hetero-nuclear NMR-based
metabolomics by uniform stable isotope labeling into Arabidopsis thaliana.
第44回NMR討論会, 横浜 (2005).
Chikayama, E., Sekiyama, Y., Hirayama, T., Shinozaki, K., Saito, K. &
Kikuchi, J. "Toward highly efficient molecular identification program
in a hetero-nuclear NMR-based metabonomics" 第44回NMR討論会, 横浜 (2005).
Suto, M., Nishihara, T., Tsuboi, Y., Hirayama T. & Kikuchi, J. "Molecular
identification of uniformly stable isotope labeled animal cells for a
hetero-nuclear NMR-based metabonomics" 第44回NMR討論会, 横浜 (2005).
菊地淳、関山恭代、近山英輔、坪井裕理、斉藤和季、篠崎一雄、平山隆志 "動植物個体均一安定同位体標識化による生細胞・抽出物の多次元NMR計測技術高度化の試み" 第47回天然有機化合物討論会、徳島
(2005)
菊地淳 "動植物界の化合物動態解析を見据えた多次元NMRメタボロ(ノ)ミクス" 第46回植物生理学会年会 "植物ホルモンとケミカルバイオロジー"シンポジウム招待課題、新潟
(2005).
赤嶺健二、平山隆志、菊地淳 "多次元NMRメタボロミクス法による植物の化合物動態解析" 第46回植物生理学会年会 "新潟
(2005).
須藤倫考、西原崇、菊地淳 "均一安定同位体標識化動物の多次元NMRメタボノミクスの試み"日本農芸化学会2005年度大会 札幌 (2005).
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